Now live · phagecocktails.com
The most precise antibiotic ever discovered is a virus.
Antimicrobial resistance is on track to kill ten million people a year by 2050, and the therapy with the right mechanism to answer it has been sitting in plain sight for a century. I bought phagecocktails.com years before most people had heard the word. It is built now. Here is the case, and the door in.
Antibiotics carpet-bomb. Phages are snipers.
A broad-spectrum antibiotic kills across the whole community, including the beneficial organisms a body is built on. A phage targets one strain, replicates only where its host is present, and disappears when the host is gone. That specificity is the entire point.
The stakes
The number everyone has agreed to ignore, set next to the mechanism that could answer it.
The flagship program
Where it should be used first: the NICU
Premature infants die from infections that should be survivable, increasingly driven by multidrug-resistant Klebsiella and related organisms in necrotizing enterocolitis. An antibiotic given to a newborn incinerates the founding microbiome at the exact moment it is being set for life. A phage removes the one organism killing the infant and leaves the rest intact. That is lethal precision in the patients who can least afford collateral damage.
From signature to cocktail
The synthesis almost no one is building: a decade of microbiome-signature work becomes the targeting system for the cocktail.
Inside phagecocktails.com
The platform goes deep. A few doors in.
Questions
What is a phage cocktail?
A bacteriophage is a virus that infects bacteria and nothing else. A phage cocktail is a tailored combination of phages assembled to target a specific infection, removing the pathogen while leaving the rest of the microbiome intact.
How is this different from antibiotics?
A broad-spectrum antibiotic kills across the entire bacterial community, including the beneficial organisms a body depends on. A phage targets a single strain. Antibiotics carpet-bomb; phages snipe.
Is phage therapy actually proven?
It has a century of clinical use. The Eliava Institute in Tbilisi, Georgia has treated patients with phage preparations since 1923, and Western compassionate-use cases, including the 2017 Patterson rescue at UC San Diego and the 2019 Mycobacterium abscessus case published in Nature Medicine, recovered patients after every antibiotic had failed.
Why the focus on premature infants?
The neonatal intensive care unit is where the stakes are sharpest. Multidrug-resistant Klebsiella and related organisms drive necrotizing enterocolitis, and a broad-spectrum antibiotic given to a newborn incinerates the founding microbiome at the moment it is being established. A phage removes the organism that is killing the infant and leaves the developing ecosystem intact.
How do microbiome signatures fit in?
A microbiome signature identifies exactly which organisms are driving a disease, which makes it the targeting system for a cocktail. The signature tells you which phages to load. That is what turns phage therapy into precision medicine.
Can I get treatment now?
No. phagecocktails.com is a scientific education and research platform, not a treatment provider, and the waitlist is interest registration only. If you need access to phage therapy today, start with the access resources on the site.
Be early on this one too
When push comes to shove, phages are what the cabinet has with the right mechanism. The people who keep the knowledge alive will look prescient. Get on the list and I will route you what matters as this gets built.
Need access today? Compassionate-use resources ↗
Read more: I built phagecocktails.com · the original case